CJC-1295 DAC

$90

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Le CJC-1295 DAC est un peptide de libération de l’hormone de croissance (GHRH) à action prolongée. Reconnu en recherche scientifique pour sa capacité à stimuler la sécrétion naturelle de GH, favoriser la récupération musculaire et améliorer la composition corporelle.

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Research Use Only: This product is intended exclusively for research applications.
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Catégorie: Performance & Récupération

Peptides Informations
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Peptides Informations

CJC-1295 DAC (DAC:GRF) is a synthetic 29 amino acid analog of growth hormone-releasing hormone (GHRH), developed by ConjuChem. It incorporates a Drug Affinity Complex (DAC) that dramatically extends its half-life to approximately 8 days, compared to minutes for native GHRH.

OVERVIEW

CJC-1295 DAC is a tetrasubstituted version of GHRH 1-29, with substitutions at positions 2, 8, 15, and 27 to improve enzymatic resistance. Its DAC element — an N-epsilon-3-maleimidopropionamide derivative linked at the C-terminus — enables covalent binding to plasma albumin, extending half-life from minutes to 6–8 days.

This mechanism allows sustained, continuous GH secretion, unlike CJC-1295 without DAC (Mod GRF 1-29) which produces more physiological pulsatile release. Both forms show comparable affinity for GHRH receptors.

RESEARCH AREAS

GH & IGF-1 — 46% increase in GH and 45% in IGF-1 (2006 clinical study); 2- to 10-fold elevation of plasma GH concentrations depending on dose.

Somatotroph proliferation — increase in total pituitary RNA and GH mRNA suggesting somatotroph cell proliferation (confirmed by immunohistochemistry).

Body composition — potential increase in lean mass, reduction of fat mass via IGF-1; JAK-STAT protein synthesis pathway.

Sleep — studies suggesting GHRH supports CNS sleep centers; mechanism potentially shared by analogs such as CJC-1295 DAC.

CHEMICAL DATA

Molecular formula	C₁₅₂H₂₅₂N₄₄O₄₂
Molecular weight	3,367.95 g/mol
Other names	DAC:GRF, Long-acting GHRH analog
Form	Lyophilized powder
Purity	>99% HPLC