SLU-PP-332 is a synthetic compound developed at Saint Louis University, a pan-ERR agonist of nuclear receptors ERRα, ERRβ, and ERRγ (estrogen-related receptors). It is classified as an exercise mimetic — a molecule that pharmacologically reproduces the cellular adaptations of aerobic physical activity.
The central molecular mechanism of SLU-PP-332 relies on ERRα activation, which controls gene networks governing oxidative metabolism, mitochondrial biogenesis, and energy homeostasis. These pathways are naturally activated by endurance exercise — SLU-PP-332 reproduces them without physical exertion.
Notably, SLU-PP-332 induces DDIT4 expression specifically via ERRα, recapitulating a key genetic response observed after short bouts of human aerobic exercise. Its doping potential has been identified by WADA (World Anti-Doping Agency).
| Molecular weight | ~382 Da |
| Targets | ERRα (EC50 98 nM), ERRβ (230 nM), ERRγ (430 nM) |
| Other names | Pan-ERR agonist, Exercise mimetic |
| Form | Powder / Solution |
| Purity | >99% HPLC |
























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