CJC-1295 + Ipamorelin

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The CJC-1295 + Ipamorelin combo combines two complementary secretagogue peptides for optimal and sustained growth hormone stimulation. Recognized in research for its effects on body composition, muscle recovery and anti-aging. For research use only.

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CJC-1295 + Ipamorelin is a blend of two growth hormone secretagogues (GHS). CJC-1295 is a tetrasubstituted version of GHRH 1-29 comprising 29 amino acids; Ipamorelin is a selective pentapeptide acting on GHS-R1a receptors. Their combination creates a synergistic pharmacokinetic profile.

OVERVIEW

Ipamorelin acts first, with a GH peak at 0.67 h and a half-life of 2 hours. As it wanes, CJC-1295 takes over with a half-life of 5.8–8.1 days, maintaining prolonged secretion. A single introduction of CJC-1295 may increase GH by 46% and IGF-1 by 45% on average.

CJC-1295 binds covalently to blood albumin via its DAC (Drug Affinity Complex) element, extending its half-life from 10 minutes to several days. It also maintains the natural pulsatility of GH, unlike other analogs.

RESEARCH AREAS
GH secretion — 7.5-fold increase in GH pulsatility vs. placebo; 2- to 10-fold elevation of GH concentrations per studies.
IGF-1 — average 45% increase in IGF-1; prolonged maintenance of plasma levels via CJC-1295’s long half-life.
Somatotroph cells — possible proliferation of GH-producing cells in the anterior pituitary (confirmed by immunohistochemistry).
Nitrogen balance — suggested synergistic anabolic action; potential reduction of urea-N synthesis in artificially induced catabolic states.

CHEMICAL DATA
CJC-1295 formula C₁₅₂H₂₅₂N₄₄O₄₂
CJC-1295 mol. weight 3,367.9 g/mol
Ipamorelin formula C₃₈H₄₉N₉O₅
Ipamorelin mol. weight 711.86 g/mol
Form Lyophilized powder
Purity >99% HPLC

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